Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 1.449


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA7chr7_-_27162688-0.504.9e-02Click!
HOXB7chr17_-_440433610.283.0e-01Click!
HOXA6chr7_-_27153892-0.175.3e-01Click!
HOXB6chr17_-_440373320.039.1e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_113853790 5.431 NM_001172767
NM_148899
 FOXP2

forkhead box P2

chr2_-_55090759 3.995 NM_007008
 RTN4
reticulon 4
chr10_-_126706442 2.927 NM_022802
 CTBP2
C-terminal binding protein 2
chr2_-_55053398 2.919


chr11_+_101488380 2.744 NM_001195045
 YAP1
Yes-associated protein 1
chr20_+_11846536 2.285 NM_014962
 BTBD3
BTB (POZ) domain containing 3
chr9_-_14076901 2.278 NFIB
nuclear factor I/B
chr2_-_200033445 2.206 SATB2
SATB homeobox 2
chr6_+_64344307 2.167 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr14_-_94669547 2.122 NM_001195573
 DICER1
dicer 1, ribonuclease type III
chr8_+_9990471 1.987 NM_001135671
 MSRA
methionine sulfoxide reductase A
chr3_+_70068440 1.980 NM_000248
NM_001184968
NM_198158
NM_198178
 MITF



microphthalmia-associated transcription factor



chr8_+_104900591 1.937 NM_014677
 RIMS2
regulating synaptic membrane exocytosis 2
chr2_+_225973845 1.921 NM_020864
 KIAA1486
KIAA1486
chr6_+_88021644 1.892 ZNF292
zinc finger protein 292
chr17_-_1195096 1.878 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr6_+_21701942 1.804 NM_003107
 SOX4
SRY (sex determining region Y)-box 4
chr2_+_211166323 1.798 NM_001122634
 CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr12_-_52281050 1.786 NM_001130059
 ATF7
activating transcription factor 7
chr3_-_121117647 1.778 GSK3B
glycogen synthase kinase 3 beta

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 80 entries
enrichment   p-value GO term description
2.33 2.37e-07 GO:0007156 homophilic cell adhesion
2.23 7.59e-03 GO:0048706 embryonic skeletal system development
1.96 1.62e-03 GO:0045165 cell fate commitment
1.87 4.35e-11 GO:0007608 sensory perception of smell
1.86 3.05e-12 GO:0007606 sensory perception of chemical stimulus
1.79 2.72e-04 GO:0050767 regulation of neurogenesis
1.76 1.33e-05 GO:0060284 regulation of cell development
1.72 1.62e-04 GO:0016337 cell-cell adhesion
1.72 2.79e-02 GO:0045664 regulation of neuron differentiation
1.71 4.95e-02 GO:0048732 gland development
1.69 1.55e-03 GO:0051960 regulation of nervous system development
1.66 1.88e-13 GO:0007600 sensory perception
1.66 9.67e-03 GO:0045596 negative regulation of cell differentiation
1.66 2.56e-02 GO:0003002 regionalization
1.60 2.98e-07 GO:0045893 positive regulation of transcription, DNA-dependent
1.59 1.29e-10 GO:0048699 generation of neurons
1.58 8.80e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.58 9.11e-03 GO:0007411 axon guidance
1.57 1.35e-10 GO:0022008 neurogenesis
1.57 3.21e-07 GO:0010628 positive regulation of gene expression

Gene overrepresentation in compartment category:

Showing 1 to 8 of 8 entries
enrichment   p-value GO term description
1.73 1.02e-02 GO:0005882 intermediate filament
1.63 2.75e-02 GO:0045111 intermediate filament cytoskeleton
1.45 1.66e-02 GO:0045202 synapse
1.39 5.35e-03 GO:0030054 cell junction
1.20 3.08e-08 GO:0005886 plasma membrane
1.19 7.89e-08 GO:0071944 cell periphery
1.03 5.88e-03 GO:0044464 cell part
1.03 6.15e-03 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
1.91 5.75e-12 GO:0004984 olfactory receptor activity
1.74 3.98e-03 GO:0003682 chromatin binding
1.67 1.42e-02 GO:0000975 regulatory region DNA binding
1.67 1.42e-02 GO:0001067 regulatory region nucleic acid binding
1.67 1.42e-02 GO:0044212 transcription regulatory region DNA binding
1.61 9.04e-10 GO:0043565 sequence-specific DNA binding
1.57 3.59e-03 GO:0016563 transcription activator activity
1.51 2.72e-10 GO:0001071 nucleic acid binding transcription factor activity
1.51 2.72e-10 GO:0003700 sequence-specific DNA binding transcription factor activity
1.47 8.18e-09 GO:0030528 transcription regulator activity
1.43 9.61e-06 GO:0004930 G-protein coupled receptor activity
1.36 2.05e-02 GO:0005509 calcium ion binding
1.31 2.20e-04 GO:0004888 transmembrane receptor activity
1.26 2.20e-04 GO:0004872 receptor activity
1.24 2.28e-04 GO:0004871 signal transducer activity
1.24 2.28e-04 GO:0060089 molecular transducer activity